The 12th century church of St. Panteleimon contemplates Macedonia’s capital city in untroubled serenity from the tiny village of Gorno Nerezi, high on the forested slopes of Mt. Vodno. Only a 15 minute drive  from downtown Skopje, the church, which is one of the oldest and most important in Macedonia, was built and painted in 1164 under patronage of Byzantine prince Alexios Komnenos, whose name is immortalized in marble above the entrance to the church. It was dedicated to St. Panteleimon, the protector of health.

The monastery is most famous for its exceptional fresco paintings, which convey dramatic facial expression and emotions not commonly found in Byzantine art. In 1555 the main dome collapsed, but within a short time the monastery was renewed and repainted. Fragments of old frescoes were incorporated into the new ones. An example of a combination of a new and old painting is the fresco portrayal of The Communion of the Apostles. Among other well-known fresco themes are the Transfiguration, the Raising of Lazarus, the Birth of the Mother of God, the Presentation of the Mother of God to the Temple, The Entry into Jerusalem, and The Descent from the Cross.

The most impressive fresco in St Panteleimon, created under the influence of apocryphal religious literature, is The Lamentation of Christ. Art historians consider it a masterpiece, as it displays traits associated with renaissance art at a much earlier date than the blossoming of the Italian Renaissance