Sveti Nikole (St. Nicholas) is the center of a region called Ovce Pole (plain of sheep), famous for sheep farming, lamb meat, and dairy products of all kinds. According to legend, the town was named after the church of Sveti Nikola, built in the beginning of the 14th century.
The outlying villages of Sveti Nikole include Amzabegovo, with its barely excavated archaeological site, and Burilovci, famous for the magnificent frescoes paintings that adorn its own church of St. Nicholas.